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[[Image:2bpu.gif|left|200px]]<br />
<applet load="2bpu" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2bpu, resolution 1.35&Aring;" />
'''THE KEDGE HOLMIUM DERIVATIVE OF HEN EGG-WHITE LYSOZYME AT HIGH RESOLUTION FROM SINGLE WAVELENGTH ANOMALOUS DIFFRACTION'''<br />


==About this Structure==
==The Kedge Holmium Derivative of Hen Egg-White Lysozyme at high resolution from Single Wavelength Anomalous Diffraction==
2BPU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with CL, NA and HO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Lysozyme Lysozyme]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BPU OCA]].
<StructureSection load='2bpu' size='340' side='right'caption='[[2bpu]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2bpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HO:HOLMIUM+ATOM'>HO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpu OCA], [https://pdbe.org/2bpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpu RCSB], [https://www.ebi.ac.uk/pdbsum/2bpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bpu ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Di Michiel M]]
[[Category: Honkimaki, V.]]
[[Category: Honkimaki V]]
[[Category: Jakoncic, J.]]
[[Category: Jakoncic J]]
[[Category: Jouanneau, Y.]]
[[Category: Jouanneau Y]]
[[Category: Michiel, M.Di.]]
[[Category: Stojanoff V]]
[[Category: Stojanoff, V.]]
[[Category: Zhong Z]]
[[Category: Zhong, Z.]]
[[Category: CL]]
[[Category: HO]]
[[Category: NA]]
[[Category: allergen]]
[[Category: compton]]
[[Category: experimental phases]]
[[Category: glycosidase]]
[[Category: high resolution]]
[[Category: holmium]]
[[Category: hydrolase bacteriolytic enzyme]]
[[Category: kedge]]
[[Category: sad]]
[[Category: ultra high energy]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:44:54 2007''

Latest revision as of 07:34, 9 October 2024

The Kedge Holmium Derivative of Hen Egg-White Lysozyme at high resolution from Single Wavelength Anomalous Diffraction

2bpu, resolution 1.35Å

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