4o9d: Difference between revisions

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{{STRUCTURE_4o9d|  PDB=4o9d  |  SCENE=  }}
===Structure of Dos1 propeller===
{{ABSTRACT_PUBMED_24449894}}


==Function==
==Structure of Dos1 propeller==
[[http://www.uniprot.org/uniprot/RAF1_SCHPO RAF1_SCHPO]] Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.<ref>PMID:16024659</ref> <ref>PMID:16040243</ref> <ref>PMID:16157682</ref>
<StructureSection load='4o9d' size='340' side='right'caption='[[4o9d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4o9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9D FirstGlance]. <br>
[[4o9d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9D OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9d OCA], [https://pdbe.org/4o9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9d RCSB], [https://www.ebi.ac.uk/pdbsum/4o9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9d ProSAT]</span></td></tr>
<ref group="xtra">PMID:024449894</ref><references group="xtra"/><references/>
</table>
[[Category: Joshua-Tor, L.]]
== Function ==
[[Category: Kuscu, C.]]
[https://www.uniprot.org/uniprot/RAF1_SCHPO RAF1_SCHPO] Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.<ref>PMID:16024659</ref> <ref>PMID:16040243</ref> <ref>PMID:16157682</ref>  
[[Category: Schalch, T.]]
== References ==
[[Category: Dos2]]
<references/>
[[Category: Gene regulation]]
__TOC__
[[Category: Heterochromatin formation]]
</StructureSection>
[[Category: Propeller]]
[[Category: Large Structures]]
[[Category: Rik1]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Transcription]]
[[Category: Joshua-Tor L]]
[[Category: Kuscu C]]
[[Category: Schalch T]]
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