4i1t: Difference between revisions

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~~{{STRUCTURE_4i1t| PDB=4i1t | SCENE= }}~~

~~===Crystal structure of the cap-snatching endonuclease from Pichinde virus===~~

==~~Function~~==

==Crystal structure of the cap-snatching endonuclease from Pichinde virus==

[[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

== Structural highlights ==

<table><tr><td colspan='2'>[[4i1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cali_mammarenavirus Cali mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1T FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1t OCA], [https://pdbe.org/4i1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1t RCSB], [https://www.ebi.ac.uk/pdbsum/4i1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1t ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

==~~About this Structure~~==

==See Also==

[[~~4i1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA].~~

*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]

~~[[Category:~~ RNA~~-directed~~ RNA polymerase]]

__TOC__

~~[[Category: Bussetta, C.]]~~

</StructureSection>

~~[[Category: Choi, K H.]]~~

[[Category: Cali mammarenavirus]]

[[Category: ~~Arenavirus~~]]

[[Category: Large Structures]]

[[Category: ~~Cap-snatching~~]]

[[Category: Bussetta C]]

[[Category: ~~Cap-snatching rna endonuclease~~]]

[[Category: Choi KH]]

[[Category: ~~Endonuclease]]~~

~~[[Category: L protein]]~~

~~[[Category: Pichinde virus]]~~

~~[[Category: Rna-dependent rna polymerase]]~~

~~[[Category: Viral protein]]~~

~~[[Category: Viral transcription~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4i1t|  PDB=4i1t  |  SCENE=  }}
-===Crystal structure of the cap-snatching endonuclease from Pichinde virus===
-==Function==
+==Crystal structure of the cap-snatching endonuclease from Pichinde virus==
-[[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
+<StructureSection load='4i1t' size='340' side='right'caption='[[4i1t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4i1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cali_mammarenavirus Cali mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1T FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1t OCA], [https://pdbe.org/4i1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1t RCSB], [https://www.ebi.ac.uk/pdbsum/4i1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
-==About this Structure==
+==See Also==
-[[4i1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA].
+*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
-[[Category: RNA-directed RNA polymerase]]
+__TOC__
-[[Category: Bussetta, C.]]
+</StructureSection>
-[[Category: Choi, K H.]]
+[[Category: Cali mammarenavirus]]
-[[Category: Arenavirus]]
+[[Category: Large Structures]]
-[[Category: Cap-snatching]]
+[[Category: Bussetta C]]
-[[Category: Cap-snatching rna endonuclease]]
+[[Category: Choi KH]]
-[[Category: Endonuclease]]
-[[Category: L protein]]
-[[Category: Pichinde virus]]
-[[Category: Rna-dependent rna polymerase]]
-[[Category: Viral protein]]
-[[Category: Viral transcription]]