437d: Difference between revisions

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[[Image:437d.gif|left|200px]]<br /><applet load="437d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="437d, resolution 1.6&Aring;" />
'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''<br />


==Overview==
==CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING==
Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.
<StructureSection load='437d' size='340' side='right'caption='[[437d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[437d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=437D FirstGlance]. <br>
437D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=437d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=437d OCA], [https://pdbe.org/437d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=437d RCSB], [https://www.ebi.ac.uk/pdbsum/437d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=437d ProSAT]</span></td></tr>
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10074948 10074948]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Berger, J M.]]
</StructureSection>
[[Category: Chen, L.]]
[[Category: Large Structures]]
[[Category: Egli, M.]]
[[Category: Berger JM]]
[[Category: Rich, A.]]
[[Category: Chen L]]
[[Category: Su, L.]]
[[Category: Egli M]]
[[Category: MG]]
[[Category: Rich A]]
[[Category: NA]]
[[Category: Su L]]
[[Category: pseudoknot]]
[[Category: rna]]
[[Category: triplex]]
[[Category: viral frameshifting]]
 
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