2mhs: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==NMR Structure of human Mcl-1== | |||
<StructureSection load='2mhs' size='340' side='right'caption='[[2mhs]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [https://pdbe.org/2mhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [https://www.ebi.ac.uk/pdbsum/2mhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A high-quality NMR solution structure is presented for protein hMcl-1(171-327) which comprises residues 171-327 of the human anti-apoptotic protein Mcl-1 (hMcl-1). Since this construct contains the three Bcl-2 homology (BH) sequence motifs which participate in forming a binding site for inhibitors of hMcl-1, it is deemed to be crucial for structure-based design of novel anti-cancer drugs blocking the Mcl1 related anti-apoptotic pathway. While the coordinates of an NMR solution structure for a corresponding construct of the mouse homologue (mMcl-1) are publicly available, our structure is the first atomic resolution structure reported for the 'apo form' of the human protein. Comparison of the two structures reveals that hMcl-1(171-327) exhibits a somewhat wider ligand/inhibitor binding groove as well as a different charge distribution within the BH3 binding groove. These findings strongly suggest that the availability of the human structure is of critical importance to support future design of cancer drugs. | |||
High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mhs" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aoki K]] | |||
[[Category: Lewis J]] | |||
[[Category: Liu G]] | |||
[[Category: Poppe L]] | |||
[[Category: Szyperski T]] | |||
[[Category: Yamane H]] | |||
Latest revision as of 06:05, 15 May 2024
NMR Structure of human Mcl-1
| ||||||||||||
