4oq6: Difference between revisions
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== | ==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid== | ||
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN | <StructureSection load='4oq6' size='340' side='right'caption='[[4oq6]], [[Resolution|resolution]] 1.81Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4oq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UV:4-HYDROXY-4-PROPYLBIPHENYL-3-CARBOXYLIC+ACID'>2UV</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq6 OCA], [https://pdbe.org/4oq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
== | ==See Also== | ||
[[ | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: Kunzer | </StructureSection> | ||
[[Category: Park | [[Category: Homo sapiens]] | ||
[[Category: Petros | [[Category: Large Structures]] | ||
[[Category: Song | [[Category: Kunzer AR]] | ||
[[Category: Souers | [[Category: Park C]] | ||
[[Category: Sun | [[Category: Petros AM]] | ||
[[Category: Swann | [[Category: Song D]] | ||
[[Category: Swinger | [[Category: Souers AJ]] | ||
[[Category: Wendt | [[Category: Sun C]] | ||
[[Category: Zhang | [[Category: Swann SL]] | ||
[[Category: Swinger K]] | |||
[[Category: Wendt MD]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 12:41, 1 March 2024
Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
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