4np1: Difference between revisions

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[[Image:4np1.gif|left|200px]]<br /><applet load="4np1" size="350" color="white" frame="true" align="right" spinBox="true"
caption="4np1, resolution 2.3&Aring;" />
'''NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE'''<br />


==About this Structure==
==NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE==
4NP1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus] with <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=NO:'>NO</scene> and <scene name='pdbligand=PHS:'>PHS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NP1 OCA].  
<StructureSection load='4np1' size='340' side='right'caption='[[4np1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4np1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NP1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4np1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4np1 OCA], [https://pdbe.org/4np1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4np1 RCSB], [https://www.ebi.ac.uk/pdbsum/4np1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4np1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NP1_RHOPR NP1_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/4np1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4np1 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Nitrophorin|Nitrophorin]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
[[Category: Single protein]]
[[Category: Andersen JF]]
[[Category: Andersen, J F.]]
[[Category: Montfort WR]]
[[Category: Montfort, W R.]]
[[Category: Walker FA]]
[[Category: Walker, F A.]]
[[Category: Weichsel A]]
[[Category: Weichsel, A.]]
[[Category: HEM]]
[[Category: NO]]
[[Category: PHS]]
[[Category: antihistamine]]
[[Category: heme]]
[[Category: lipocalin]]
[[Category: nitric oxide transport]]
[[Category: vasodilator]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:13:52 2008''
Retrieved from "https://proteopedia.org/4np1"