4nah: Difference between revisions

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~~{{STRUCTURE_4nah| PDB=4nah | SCENE= }}~~

~~===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)===~~

~~{{ABSTRACT_PUBMED_24041904}}~~

==~~Function~~==

==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)==

[[~~http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW~~]] ~~Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine~~, ~~yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)~~.

== Structural highlights ==

==~~About this Structure~~==

<table><tr><td colspan='2'>[[4nah]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAH OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4NAH FirstGlance].

[[4nah]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAH OCA].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VJ:2-[(2-{(1S,2S)-2-[(3,4-DICHLOROBENZYL)CARBAMOYL]CYCLOHEXYL}-6-ETHYLPYRIMIDIN-4-YL)SULFANYL]-1H-IMIDAZOLE-5-CARBOXYLIC+ACID'>2VJ</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>

==~~Reference~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4nah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nah OCA], [https://pdbe.org/4nah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nah RCSB], [https://www.ebi.ac.uk/pdbsum/4nah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nah ProSAT]</td></tr>

<~~ref group~~="~~xtra~~">~~PMID~~:~~024041904~~</~~ref~~><~~references group~~="~~xtra~~"/><~~references~~/>

</table>

[[~~Category~~: ~~Pantetheine~~-~~phosphate adenylyltransferase~~]]

== Function ==

[[~~Category~~: ~~Lahiri~~, ~~S D~~.]]

[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).

[[Category: ~~Phosphopanthetheine~~]]

__TOC__

[[Category: ~~Phosphopanthetheine adenylyltransferase~~]]

</StructureSection>

[[Category: ~~Transferase-transferase inhibitor complex~~]]

[[Category: Large Structures]]

[[Category: Staphylococcus aureus subsp. aureus MW2]]

[[Category: Lahiri SD]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4nah|  PDB=4nah  |  SCENE=  }}
-===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)===
-{{ABSTRACT_PUBMED_24041904}}
-==Function==
+==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)==
-[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
+<StructureSection load='4nah' size='340' side='right'caption='[[4nah]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[4nah]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAH FirstGlance]. <br>
-[[4nah]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAH OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VJ:2-[(2-{(1S,2S)-2-[(3,4-DICHLOROBENZYL)CARBAMOYL]CYCLOHEXYL}-6-ETHYLPYRIMIDIN-4-YL)SULFANYL]-1H-IMIDAZOLE-5-CARBOXYLIC+ACID'>2VJ</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nah OCA], [https://pdbe.org/4nah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nah RCSB], [https://www.ebi.ac.uk/pdbsum/4nah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nah ProSAT]</span></td></tr>
-<ref group="xtra">PMID:024041904</ref><references group="xtra"/><references/>
+</table>
-[[Category: Pantetheine-phosphate adenylyltransferase]]
+== Function ==
-[[Category: Lahiri, S D.]]
+[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
-[[Category: Phosphopanthetheine]]
+__TOC__
-[[Category: Phosphopanthetheine adenylyltransferase]]
+</StructureSection>
-[[Category: Transferase-transferase inhibitor complex]]
+[[Category: Large Structures]]
+[[Category: Staphylococcus aureus subsp. aureus MW2]]
+[[Category: Lahiri SD]]