Granzyme: Difference between revisions
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<StructureSection load=' | <StructureSection load='1iau' size='400' side='right' caption='Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry [[1iau]])' scene='51/517375/Cv/1'> | ||
== Function == | |||
'''Granzymes''' (GZM) or '''cytotoxic T-lymphocyte proteinase 1''' are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | |||
*'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br /> | |||
*'''Granzyme B and C''' induce cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br /> | |||
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | |||
*'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br /> | |||
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | |||
''' | == Structural highlights == | ||
The <scene name='51/517375/Cv/6'>active site</scene> of human GZMB contains the <scene name='51/517375/Cv/7'>typical serine protease catalytic triad</scene> and <scene name='51/517375/Cv/8'>oxyanion hole</scene><ref>PMID:11325591</ref>. | |||
</StructureSection> | |||
==3D structures of granzyme== | ==3D structures of granzyme== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Granzyme A | |||
[[1op8]] – hGZM<br /> | **[[1op8]] – hGZM<br /> | ||
[[1orf]] – hGZM (mutant) | **[[1orf]] – hGZM (mutant) | ||
*Granzyme B | |||
[[1fi8]] – GZM (mutant) + ecotin – rat<br /> | **[[1fi8]] – GZM (mutant) + ecotin – rat<br /> | ||
[[1fq3]] – hGZM<br /> | **[[1fq3]] – hGZM<br /> | ||
[[1iau]] – hGZM + polypeptide<br /> | **[[1iau]] – hGZM + polypeptide<br /> | ||
*Granzyme C | |||
[[3fzz]] – mGZM – mouse<br /> | **[[3fzz]] – mGZM – mouse<br /> | ||
[[3g01]] – mGZM (mutant) | **[[3g01]] – mGZM (mutant) | ||
*Granzyme H | |||
[[4gaw]] – hGZM<br /> | **[[4gaw]] – hGZM<br /> | ||
[[3tk9]] - hGZM (mutant) <br /> | **[[3tk9]] - hGZM (mutant) <br /> | ||
[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br /> | **[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br /> | ||
*Granzyme K | |||
[[1mza]], [[1mzd]] – h-proGZM (mutant) | **[[1mza]], [[1mzd]] – h-proGZM (mutant) | ||
*Granzyme M | |||
[[2zgc]] – hGZM<br /> | **[[2zgc]] – hGZM<br /> | ||
[[2zgh]], [[2zks]] - hGZM + polypeptide<br /> | **[[2zgh]], [[2zks]] - hGZM + polypeptide<br /> | ||
[[2zgj]] – hGZM (mutant) + polypeptide<br /> | **[[2zgj]] – hGZM (mutant) + polypeptide<br /> | ||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
