4pvs: Difference between revisions
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New page: {{STRUCTURE_4pvs| PDB=4pvs | SCENE= }} ===Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate=== {{ABSTRACT_PUBMED_22861376}} ==Function== [[h... |
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== | ==Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate== | ||
[[http://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN | <StructureSection load='4pvs' size='340' side='right'caption='[[4pvs]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gdw 4gdw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvs OCA], [https://pdbe.org/4pvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvs RCSB], [https://www.ebi.ac.uk/pdbsum/4pvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref> | |||
== | ==See Also== | ||
[[ | *[[Asparaginase 3D structures|Asparaginase 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Lavie A]] | ||
[[Category: Nomme J]] | |||
Latest revision as of 12:43, 1 March 2024
Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate
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