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{{STRUCTURE_4o4l|  PDB=4o4l  |  SCENE=  }}
===Tubulin-Peloruside A-Epothilone A complex===
{{ABSTRACT_PUBMED_24470331}}


==Function==
==Tubulin-Peloruside A-Epothilone A complex==
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).  
<StructureSection load='4o4l' size='340' side='right'caption='[[4o4l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o4l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POU:PELORUSIDE+A'>POU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4l OCA], [https://pdbe.org/4o4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4l RCSB], [https://www.ebi.ac.uk/pdbsum/4o4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


==About this Structure==
==See Also==
[[4o4l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4L OCA].
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
 
*[[Tubulin tyrosine ligase 3D structures|Tubulin tyrosine ligase 3D structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:024470331</ref><references group="xtra"/><references/>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Altmann, K H.]]
[[Category: Gallus gallus]]
[[Category: Bargsten, K.]]
[[Category: Large Structures]]
[[Category: Diaz, J F.]]
[[Category: Rattus norvegicus]]
[[Category: Marsh, M.]]
[[Category: Altmann KH]]
[[Category: Miller, J H.]]
[[Category: Bargsten K]]
[[Category: Northcote, P T.]]
[[Category: Diaz JF]]
[[Category: Prota, A E.]]
[[Category: Marsh M]]
[[Category: Steinmetz, M O.]]
[[Category: Miller JH]]
[[Category: Alpha-tubulin]]
[[Category: Northcote PT]]
[[Category: Beta-tubulin]]
[[Category: Prota AE]]
[[Category: Cell cycle-inhibitor complex]]
[[Category: Steinmetz MO]]
[[Category: Cytoskeleton]]
[[Category: Epothilone some]]
[[Category: Gtpase]]
[[Category: Ligase]]
[[Category: Microtubule]]
[[Category: Peloruside some]]
[[Category: Stathmin]]
[[Category: Tubulin fold]]
Retrieved from "https://proteopedia.org/4o4l"