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{{STRUCTURE_4nck|  PDB=4nck  |  SCENE=  }}
===Crystal Structure of Pyrococcus furiosis Rad50 R797G mutation===
{{ABSTRACT_PUBMED_24493214}}


==Function==
==Crystal Structure of Pyrococcus furiosis Rad50 R797G mutation==
[[http://www.uniprot.org/uniprot/RAD50_PYRFU RAD50_PYRFU]] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449]  
<StructureSection load='4nck' size='340' side='right'caption='[[4nck]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nck]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nck OCA], [https://pdbe.org/4nck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nck RCSB], [https://www.ebi.ac.uk/pdbsum/4nck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nck ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAD50_PYRFU RAD50_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449]


==About this Structure==
==See Also==
[[4nck]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCK OCA].
*[[ATPase 3D structures|ATPase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024493214</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Arvai, A S.]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Classen, S.]]
[[Category: Arvai AS]]
[[Category: Williams, G J.]]
[[Category: Classen S]]
[[Category: Williams, R S.]]
[[Category: Williams GJ]]
[[Category: Adenosine triphosphatase]]
[[Category: Williams RS]]
[[Category: Dna binding protein]]
[[Category: Dna repair]]
[[Category: Fungal protein]]
Retrieved from "https://proteopedia.org/4nck"