2mn2: Difference between revisions

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New page: '''Unreleased structure''' The entry 2mn2 is ON HOLD Authors: Marimon, O., Cordeiro, T.N., Amata, I., Pons, M. Description: 3D structure of YmoB. A modulator of biofilm formation.
 
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'''Unreleased structure'''


The entry 2mn2 is ON HOLD
==3D structure of YmoB, a modulator of biofilm formation==
<StructureSection load='2mn2' size='340' side='right'caption='[[2mn2]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MN2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn2 OCA], [https://pdbe.org/2mn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0E1NKQ3_YEREN A0A0E1NKQ3_YEREN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In contrast to other TA systems, [C117S]YmoB transiently interacts with Hha (rather than forming a stable complex) and enhances the spontaneous oxidation of the Hha conserved cysteine residue to a -SOxH-containing species (sulfenic, sulfinic or sulfonic acid), which destabilizes the toxin. The nuclear magnetic resonance structure of [C117S]YmoB and the homology model of TomB show that the two proteins form a four-helix bundle with a conserved buried cysteine connected to the exterior by a channel with a diameter comparable to that of an oxygen molecule. The Hha interaction site is located on the opposite side of the helix bundle.


Authors: Marimon, O., Cordeiro, T.N., Amata, I., Pons, M.
An oxygen-sensitive toxin-antitoxin system.,Marimon O, Teixeira JM, Cordeiro TN, Soo VW, Wood TL, Mayzel M, Amata I, Garcia J, Morera A, Gay M, Vilaseca M, Orekhov VY, Wood TK, Pons M Nat Commun. 2016 Dec 8;7:13634. doi: 10.1038/ncomms13634. PMID:27929062<ref>PMID:27929062</ref>


Description: 3D structure of YmoB. A modulator of biofilm formation.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mn2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia enterocolitica]]
[[Category: Amata I]]
[[Category: Cordeiro TN]]
[[Category: Marimon O]]
[[Category: Pons M]]
Retrieved from "https://proteopedia.org/2mn2"