2mn3: Difference between revisions
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==Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)== | |||
<StructureSection load='2mn3' size='340' side='right'caption='[[2mn3]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MN3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn3 OCA], [https://pdbe.org/2mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DEFBL_ORNAN DEFBL_ORNAN] Has antimicrobial activity. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The three-dimensional structure of a chemically synthesized peptide that we have called 'intermediate' defensin-like peptide (Int-DLP), from the platypus genome, was determined by nuclear magnetic resonance (NMR) spectroscopy; and its antimicrobial activity was investigated. The overall structural fold of Int-DLP was similar to that of the DLPs and beta-defensins, however the presence of a third antiparallel beta-strand makes its structure more similar to the beta-defensins than the DLPs. Int-DLP displayed potent antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The four arginine residues at the N-terminus of Int-DLP did not affect the overall fold, but were important for its antimicrobial potency. | |||
Structure and antimicrobial activity of platypus 'intermediate' defensin-like peptide.,Torres AM, Bansal P, Koh JM, Pages G, Wu MJ, Kuchel PW FEBS Lett. 2014 May 2;588(9):1821-6. doi: 10.1016/j.febslet.2014.03.044. Epub, 2014 Mar 30. PMID:24694388<ref>PMID:24694388</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mn3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ornithorhynchus anatinus]] | |||
[[Category: Bansal PS]] | |||
[[Category: Koh JMS]] | |||
[[Category: Kuchel PW]] | |||
[[Category: Pages G]] | |||
[[Category: Torres AM]] | |||
[[Category: Wu MJ]] | |||
Latest revision as of 08:19, 30 October 2024
Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)
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