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[[Image:2rcq.jpg|left|200px]]<br /><applet load="2rcq" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2rcq, resolution 1.200&Aring;" />
'''Crystal strucure of human apo Cellular Retinol Binding Protein II (CRBP-II)'''<br />


==About this Structure==
==Crystal structure of human apo Cellular Retinol Binding Protein II (CRBP-II)==
2RCQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=TLA:'>TLA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+151'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+152'>AC2</scene> and <scene name='pdbsite=AC3:Tla+Binding+Site+For+Residue+A+150'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCQ OCA].  
<StructureSection load='2rcq' size='340' side='right'caption='[[2rcq]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rcq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcq OCA], [https://pdbe.org/2rcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcq RCSB], [https://www.ebi.ac.uk/pdbsum/2rcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcq ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution., Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL, Proteins. 2007 Dec 12;70(4):1626-1630. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18076076 18076076]
*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Capaldi, S.]]
[[Category: Capaldi S]]
[[Category: Monaco, H L.]]
[[Category: Monaco HL]]
[[Category: Perduca, M.]]
[[Category: Perduca M]]
[[Category: SO4]]
[[Category: TLA]]
[[Category: cellular retinol binding protein ii]]
[[Category: crbp-ii]]
[[Category: cytoplasm]]
[[Category: lipid-binding protein]]
[[Category: retinol]]
[[Category: retinol-binding]]
[[Category: retinol-binding protein]]
[[Category: transport]]
[[Category: vitamin a]]
[[Category: x-ray]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 27 07:48:00 2008''

Latest revision as of 11:54, 30 August 2023

Crystal structure of human apo Cellular Retinol Binding Protein II (CRBP-II)

2rcq, resolution 1.20Å

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