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{{STRUCTURE_2m2w|  PDB=2m2w  |  SCENE=  }}
===Ternary complex of ASFV Pol X with DNA and MgdGTP===
{{ABSTRACT_PUBMED_24617852}}


==Function==
==Ternary complex of ASFV Pol X with DNA and MgdGTP==
[[http://www.uniprot.org/uniprot/DPOLX_ASFB7 DPOLX_ASFB7]] Error-prone polymerase lacking a proofreading 3'-5' exonuclease which plays a role in viral DNA repair. Specifically binds intermediates in the single-nucleotide base-excision repair process. Also catalyzes DNA polymerization with low nucleotide-insertion fidelity. Together with the viral DNA ligase, fills the single nucleotide gaps generated by the AP endonuclease.<ref>PMID:12595253</ref> <ref>PMID:11685239</ref>
<StructureSection load='2m2w' size='340' side='right'caption='[[2m2w]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2w OCA], [https://pdbe.org/2m2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2w RCSB], [https://www.ebi.ac.uk/pdbsum/2m2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOLX_ASFB7 DPOLX_ASFB7] Error-prone polymerase lacking a proofreading 3'-5' exonuclease which plays a role in viral DNA repair. Specifically binds intermediates in the single-nucleotide base-excision repair process. Also catalyzes DNA polymerization with low nucleotide-insertion fidelity. Together with the viral DNA ligase, fills the single nucleotide gaps generated by the AP endonuclease.<ref>PMID:12595253</ref> <ref>PMID:11685239</ref>  


==About this Structure==
==See Also==
[[2m2w]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2W OCA].
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024617852</ref><references group="xtra"/><references/>
__TOC__
[[Category: DNA-directed DNA polymerase]]
</StructureSection>
[[Category: Su, M.]]
[[Category: African swine fever virus]]
[[Category: Tsai, M.]]
[[Category: Large Structures]]
[[Category: Wu, W.]]
[[Category: Su M]]
[[Category: Asfv pol x]]
[[Category: Tsai M]]
[[Category: Dna polymerase]]
[[Category: Wu W]]
[[Category: Nucleotidyl transferase]]
[[Category: Transferase-dna complex]]
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