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{{STRUCTURE_3wdl|  PDB=3wdl  |  SCENE=  }}
===Crystal structure of 4-phosphopantoate-beta-alanine ligase complexed with ATP===
{{ABSTRACT_PUBMED_24638914}}


==Function==
==Crystal structure of 4-phosphopantoate-beta-alanine ligase complexed with ATP==
[[http://www.uniprot.org/uniprot/PPS_THEKO PPS_THEKO]] Catalyzes the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity.
<StructureSection load='3wdl' size='340' side='right'caption='[[3wdl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3wdl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WDL FirstGlance]. <br>
[[3wdl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WDL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wdl OCA], [https://pdbe.org/3wdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wdl RCSB], [https://www.ebi.ac.uk/pdbsum/3wdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wdl ProSAT]</span></td></tr>
<ref group="xtra">PMID:024638914</ref><references group="xtra"/><references/>
</table>
[[Category: 4-phosphopantoate--beta-alanine ligase]]
== Function ==
[[Category: Atomi, H.]]
[https://www.uniprot.org/uniprot/PPS_THEKO PPS_THEKO] Catalyzes the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity.
[[Category: Imanaka, T.]]
__TOC__
[[Category: Ishibashi, T.]]
</StructureSection>
[[Category: Kishimoto, A.]]
[[Category: Large Structures]]
[[Category: Kita, A.]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Miki, K.]]
[[Category: Atomi H]]
[[Category: Tomita, H.]]
[[Category: Imanaka T]]
[[Category: Yokooji, Y.]]
[[Category: Ishibashi T]]
[[Category: Ligase]]
[[Category: Kishimoto A]]
[[Category: Kita A]]
[[Category: Miki K]]
[[Category: Tomita H]]
[[Category: Yokooji Y]]

Latest revision as of 08:44, 20 March 2024

Crystal structure of 4-phosphopantoate-beta-alanine ligase complexed with ATP

3wdl, resolution 2.40Å

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