4o9c: Difference between revisions
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==Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16== | |||
<StructureSection load='4o9c' size='340' side='right'caption='[[4o9c]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o9c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_necator_H16 Cupriavidus necator H16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9C FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9c OCA], [https://pdbe.org/4o9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9c RCSB], [https://www.ebi.ac.uk/pdbsum/4o9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9c ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/THIL_CUPNH THIL_CUPNH] Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB.<ref>PMID:2670935</ref> <ref>PMID:2670936</ref> <ref>PMID:4198758</ref> | |||
==See Also== | |||
*[[Thiolase 3D structures|Thiolase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cupriavidus necator H16]] | |||
[[Category: Large Structures]] | |||
[[Category: Kim EJ]] | |||
[[Category: Kim J]] | |||
[[Category: Kim KJ]] | |||
[[Category: Kim S]] | |||
Latest revision as of 08:57, 20 March 2024
Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16
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