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{{STRUCTURE_4nft|  PDB=4nft  |  SCENE=  }}
===Crystal structure of human lnkH2B-h2A.Z-Anp32e===
{{ABSTRACT_PUBMED_24613878}}


==Function==
==Crystal structure of human lnkH2B-h2A.Z-Anp32e==
[[http://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/AN32E_HUMAN AN32E_HUMAN]] Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity).
<StructureSection load='4nft' size='340' side='right'caption='[[4nft]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nft]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nft OCA], [https://pdbe.org/4nft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nft RCSB], [https://www.ebi.ac.uk/pdbsum/4nft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nft ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> [https://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  


==About this Structure==
==See Also==
[[4nft]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA].
*[[Histone 3D structures|Histone 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024613878</ref><references group="xtra"/><references/>
__TOC__
[[Category: Chen, S.]]
</StructureSection>
[[Category: Dai, L.]]
[[Category: Homo sapiens]]
[[Category: Ding, X.]]
[[Category: Large Structures]]
[[Category: Dong, Q.]]
[[Category: Chen S]]
[[Category: Liang, X.]]
[[Category: Dai L]]
[[Category: Mao, Z.]]
[[Category: Ding X]]
[[Category: Pan, L.]]
[[Category: Dong Q]]
[[Category: Shan, S.]]
[[Category: Liang X]]
[[Category: Sun, J.]]
[[Category: Mao Z]]
[[Category: Wang, W.]]
[[Category: Pan L]]
[[Category: Zhang, Z.]]
[[Category: Shan S]]
[[Category: Zhou, Z.]]
[[Category: Sun J]]
[[Category: Zhu, B.]]
[[Category: Wang W]]
[[Category: Chaperone]]
[[Category: Zhang Z]]
[[Category: Histone binding protein]]
[[Category: Zhou Z]]
[[Category: Zhu B]]
Retrieved from "https://proteopedia.org/4nft"