Polyamine oxidase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,850 edits
No edit summary
Michal Harel (talk | contribs)
32,850 edits
No edit summary
 
(12 intermediate revisions by 3 users not shown)
Line 1: Line 1:
{{STRUCTURE_3l1r|  PDB=3l1r  | SIZE=400| SCENE= |right|CAPTION=Glycosylated FAD containing polyamine oxidase dimer complex  with spermidine, sulfate and Cl- ion (green), [[3l1r]] }}
<StructureSection load='' size='350' side='right' scene='48/486448/Cv/1' caption='lycosylated FAD containing polyamine oxidase dimer complex  with spermidine, sulfate and Cl- ion (green), [[3l1r]]' >  
<!--
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
Or use the four-green-boxes-button to insert scrollable text adjacent
to a Jmol applet. Check out the other buttons as well!
-->
'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen  and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide.  PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death.  PAO is involved in polyamine catabolism and uses FAD as a cofactor.


'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen  and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide.  PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death.  PAO is involved in polyamine catabolism and uses FAD as a cofactor<ref>PMID:8584670</ref>.<br />
'''Spermine oxidase''' (PAO-1) oxydizes spermine<ref>PMID:21809080</ref>.<br />
*<scene name='48/486448/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
*<scene name='48/486448/Cv/5'>Spermidine binding site</scene>.
*<scene name='48/486448/Cv/6'>Whole active site</scene>.
</StructureSection>
==3D structures of polyamine oxidase==
==3D structures of polyamine oxidase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Polyamine oxidase
**[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
**[[3kpf]], [[4ech]], [[4gdp]] – yPAO (mutant)<br />
**[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
*Polyamine oxidase binary complex


[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
**[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
[[3kpf]], [[4ech]], [[4gdp]] – yPAO (mutant)<br />
**[[1z6l]] - yPAO + polyamine<br />
[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
**[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
**[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
**[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
**[[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine<br />
**[[3ku9]] - mPAO FAD-binding domain (mutant) + spermine<br />


'''Polyamine oxidase binary complex'''
*Spermine oxidase or PAO-1


[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
**[[7oxl]] – hPAO-1 + FAD derivative – human<br />
[[1z6l]] - yPAO + polyamine<br />
**[[7oy0]] – hPAO-1 + FAD derivative + inhibitor<br />
[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
[[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine


}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Polyamine_oxidase"