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{{STRUCTURE_1ctw|  PDB=1ctw  |  SCENE=  }}
===T4 LYSOZYME MUTANT I78A===
{{ABSTRACT_PUBMED_10545167}}


==Function==
==T4 LYSOZYME MUTANT I78A==
[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.  
<StructureSection load='1ctw' size='340' side='right'caption='[[1ctw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ctw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTW FirstGlance]. <br>
[[1ctw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTW OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ctw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ctw OCA], [https://pdbe.org/1ctw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ctw RCSB], [https://www.ebi.ac.uk/pdbsum/1ctw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ctw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1ctw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ctw ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:010545167</ref><references group="xtra"/><references/>
__TOC__
[[Category: Bpt4]]
</StructureSection>
[[Category: Lysozyme]]
[[Category: Escherichia virus T4]]
[[Category: Baase, W A.]]
[[Category: Large Structures]]
[[Category: Gassner, N C.]]
[[Category: Baase WA]]
[[Category: Lindstrom, J D.]]
[[Category: Gassner NC]]
[[Category: Lu, J.]]
[[Category: Lindstrom JD]]
[[Category: Matthews, B W.]]
[[Category: Lu J]]
[[Category: Cavity mutant]]
[[Category: Matthews BW]]
[[Category: Hydrolase]]
[[Category: Protein engineering]]
[[Category: Protein folding]]
[[Category: T4 lysozyme]]
Retrieved from "https://proteopedia.org/1ctw"