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{{STRUCTURE_2mh2|  PDB=2mh2  |  SCENE=  }}
===Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2===


==Function==
==Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2==
[[http://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE]] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref>
<StructureSection load='2mh2' size='340' side='right'caption='[[2mh2]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2mh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MH2 FirstGlance]. <br>
[[2mh2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh2 OCA], [https://pdbe.org/2mh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh2 ProSAT]</span></td></tr>
==Reference==
</table>
<references group="xtra"/><references/>
== Function ==
[[Category: Camerini-Otero, R D.]]
[https://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref>  
[[Category: Eyter, C A.]]
== References ==
[[Category: Guiraldelli, M F.]]
<references/>
[[Category: Moktan, H.]]
__TOC__
[[Category: Pezza, R J.]]
</StructureSection>
[[Category: Sung, P.]]
[[Category: Large Structures]]
[[Category: Zhao, W.]]
[[Category: Mus musculus]]
[[Category: Zhou, D H.]]
[[Category: Camerini-Otero RD]]
[[Category: Dna binding protein]]
[[Category: Eyter CA]]
[[Category: Homologous pairing protein]]
[[Category: Guiraldelli MF]]
[[Category: Homologous recombination]]
[[Category: Moktan H]]
[[Category: Meiosis]]
[[Category: Pezza RJ]]
[[Category: Sung P]]
[[Category: Zhao W]]
[[Category: Zhou DH]]
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