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{{STRUCTURE_4o64|  PDB=4o64  |  SCENE=  }}
===Zinc fingers of KDM2B===


==Function==
==Zinc fingers of KDM2B==
[[http://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN]] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref>
<StructureSection load='4o64' size='340' side='right'caption='[[4o64]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o64]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O64 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [https://pdbe.org/4o64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [https://www.ebi.ac.uk/pdbsum/4o64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o64 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref>  


==About this Structure==
==See Also==
[[4o64]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA].
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
[[Category: Arrowsmith,C H.]]
</StructureSection>
[[Category: Bountra, C.]]
[[Category: Homo sapiens]]
[[Category: Edwards, A M.]]
[[Category: Large Structures]]
[[Category: Liu, K.]]
[[Category: Arrowsmith CH]]
[[Category: Min, J.]]
[[Category: Bountra C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Edwards AM]]
[[Category: Tempel, W.]]
[[Category: Liu K]]
[[Category: Walker, J R.]]
[[Category: Min J]]
[[Category: Xu, C.]]
[[Category: Tempel W]]
[[Category: Cxxc zinc finger]]
[[Category: Walker JR]]
[[Category: Metal binding protein]]
[[Category: Xu C]]
[[Category: Ring zinc finger]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 12:37, 1 March 2024

Zinc fingers of KDM2B

4o64, resolution 2.13Å

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