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{{STRUCTURE_4otn|  PDB=4otn  |  SCENE=  }}
===Crystal structure of the C-terminal regulatory domain of murine GCN2===


==Function==
==Crystal structure of the C-terminal regulatory domain of murine GCN2==
[[http://www.uniprot.org/uniprot/E2AK4_MOUSE E2AK4_MOUSE]] Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.  
<StructureSection load='4otn' size='340' side='right'caption='[[4otn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4otn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4otn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4otn OCA], [https://pdbe.org/4otn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4otn RCSB], [https://www.ebi.ac.uk/pdbsum/4otn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4otn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E2AK4_MOUSE E2AK4_MOUSE] Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.


==About this Structure==
==See Also==
[[4otn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTN OCA].
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
[[Category: Non-specific serine/threonine protein kinase]]
__TOC__
[[Category: Georgiadis, M M.]]
</StructureSection>
[[Category: He, H.]]
[[Category: Large Structures]]
[[Category: 4-stranded beta sheet 3 helix bundle]]
[[Category: Mus musculus]]
[[Category: C-terminal regulatory domain]]
[[Category: Georgiadis MM]]
[[Category: Gcn2]]
[[Category: He H]]
[[Category: Regulatory domain of eif2 stress kinase]]
[[Category: Transferase]]

Latest revision as of 12:41, 1 March 2024

Crystal structure of the C-terminal regulatory domain of murine GCN2

4otn, resolution 1.90Å

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