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{{STRUCTURE_1ntl|  PDB=1ntl  |  SCENE=  }}
===Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling===
{{ABSTRACT_PUBMED_12767833}}


==Function==
==Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling==
[[http://www.uniprot.org/uniprot/CR1L_MOUSE CR1L_MOUSE]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.<ref>PMID:1730912</ref> <ref>PMID:7528766</ref> <ref>PMID:10779754</ref> <ref>PMID:10642554</ref> <ref>PMID:11986227</ref>
<StructureSection load='1ntl' size='340' side='right'caption='[[1ntl]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ntl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTL FirstGlance]. <br>
[[1ntl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering, [[Resolution|Resolution]] 30&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntl OCA], [https://pdbe.org/1ntl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntl RCSB], [https://www.ebi.ac.uk/pdbsum/1ntl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntl ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:012767833</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntl ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Aslam, M.]]
[[Category: Aslam M]]
[[Category: Guthridge, J M.]]
[[Category: Guthridge JM]]
[[Category: Hack, B K.]]
[[Category: Hack BK]]
[[Category: Holers, V M.]]
[[Category: Holers VM]]
[[Category: Perkins, S J.]]
[[Category: Perkins SJ]]
[[Category: Quigg, R J.]]
[[Category: Quigg RJ]]
[[Category: Ccp]]
[[Category: Complement]]
[[Category: Glycoprotein]]
[[Category: Immune system]]
[[Category: Immunology]]
[[Category: Scr]]
Retrieved from "https://proteopedia.org/1ntl"