3c76: Difference between revisions

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New page: left|200px<br /><applet load="3c76" size="350" color="white" frame="true" align="right" spinBox="true" caption="3c76, resolution 1.07Å" /> '''1.07 A crystal struc...
 
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[[Image:3c76.jpg|left|200px]]<br /><applet load="3c76" size="350" color="white" frame="true" align="right" spinBox="true"
caption="3c76, resolution 1.07&Aring;" />
'''1.07 A crystal structure of L133V mutant of nitrophorin 4 from Rhodnius prolixus complexed with ammonia at PH 7.5'''<br />


==About this Structure==
==1.07 A crystal structure of L133V mutant of nitrophorin 4 from Rhodnius prolixus complexed with ammonia at PH 7.5==
3C76 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus] with <scene name='pdbligand=NH3:'>NH3</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 2ASZ. Known structural/functional Site: <scene name='pdbsite=AC1:Hem+Binding+Site+For+Residue+X+185'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C76 OCA].  
<StructureSection load='3c76' size='340' side='right'caption='[[3c76]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3c76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C76 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c76 OCA], [https://pdbe.org/3c76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c76 RCSB], [https://www.ebi.ac.uk/pdbsum/3c76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c76 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c76_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c76 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Nitrophorin|Nitrophorin]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
[[Category: Single protein]]
[[Category: Amoia AM]]
[[Category: Amoia, A M.]]
[[Category: Montfort WR]]
[[Category: Montfort, W R.]]
[[Category: HEM]]
[[Category: NH3]]
[[Category: beta barrel]]
[[Category: ferric heme]]
[[Category: iron]]
[[Category: lipocalin]]
[[Category: metal-binding]]
[[Category: secreted]]
[[Category: transport protein]]
[[Category: vasoactive]]
[[Category: vasodilator]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  5 13:24:32 2008''
Retrieved from "https://proteopedia.org/3c76"