4q4n: Difference between revisions
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New page: '''Unreleased structure''' The entry 4q4n is ON HOLD Authors: Squeglia, F., Ruggiero, A., Romano, M., Vitagliano, L., Berisio, R. Description: Structure of the Resuscitation Promoting ... |
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==Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at H432== | |||
<StructureSection load='4q4n' size='340' side='right'caption='[[4q4n]], [[Resolution|resolution]] 1.38Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4q4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4n OCA], [https://pdbe.org/4q4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4n RCSB], [https://www.ebi.ac.uk/pdbsum/4q4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Berisio R]] | |||
[[Category: Romano M]] | |||
[[Category: Ruggiero A]] | |||
[[Category: Squeglia F]] | |||
[[Category: Vitagliano L]] | |||
Latest revision as of 12:44, 1 March 2024
Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at H432
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