4q4t: Difference between revisions
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New page: '''Unreleased structure''' The entry 4q4t is ON HOLD Authors: Squeglia, F., Ruggiero, A., Romano, M., Vitagliano, L., Berisio, R. Description: Structure of the Resuscitation Promoting ... |
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==Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at E444== | |||
<StructureSection load='4q4t' size='340' side='right'caption='[[4q4t]], [[Resolution|resolution]] 1.63Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4q4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4t OCA], [https://pdbe.org/4q4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4t RCSB], [https://www.ebi.ac.uk/pdbsum/4q4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Berisio R]] | |||
[[Category: Romano M]] | |||
[[Category: Ruggiero A]] | |||
[[Category: Squeglia F]] | |||
[[Category: Vitagliano L]] | |||
