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{{STRUCTURE_4ndw|  PDB=4ndw  |  SCENE=  }}
===Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)===
{{ABSTRACT_PUBMED_24699733}}


==Function==
==Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)==
[[http://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU]] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>
<StructureSection load='4ndw' size='340' side='right'caption='[[4ndw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4ndw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NDW FirstGlance]. <br>
[[4ndw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDW OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ndw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ndw OCA], [https://pdbe.org/4ndw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ndw RCSB], [https://www.ebi.ac.uk/pdbsum/4ndw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ndw ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:024699733</ref><references group="xtra"/><references/>
== Function ==
[[Category: Gangwar, S P.]]
[https://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>  
[[Category: Meena, S R.]]
== References ==
[[Category: Saxena, A K.]]
<references/>
[[Category: All helical]]
__TOC__
[[Category: Dna binding]]
</StructureSection>
[[Category: Helix-turn-helix motif]]
[[Category: Large Structures]]
[[Category: Transactional regulator]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Transcription]]
[[Category: Gangwar SP]]
[[Category: Meena SR]]
[[Category: Saxena AK]]
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