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{{STRUCTURE_4obo|  PDB=4obo  |  SCENE=  }}
===MAP4K4 in complex with inhibitor (compound 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE===
{{ABSTRACT_PUBMED_24673130}}


==Function==
==MAP4K4 in complex with inhibitor (compound 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE==
[[http://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN]] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref>
<StructureSection load='4obo' size='340' side='right'caption='[[4obo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4obo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OBO FirstGlance]. <br>
[[4obo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OBO OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2QV:6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE'>2QV</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4obo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4obo OCA], [https://pdbe.org/4obo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4obo RCSB], [https://www.ebi.ac.uk/pdbsum/4obo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4obo ProSAT]</span></td></tr>
<ref group="xtra">PMID:024673130</ref><references group="xtra"/><references/>
</table>
[[Category: Non-specific serine/threonine protein kinase]]
== Function ==
[[Category: Coons, M.]]
[https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref>  
[[Category: Harris, S F.]]
== References ==
[[Category: Wu, P.]]
<references/>
[[Category: Kinase]]
__TOC__
[[Category: Transferase-transferase inhibitor complex]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Coons M]]
[[Category: Harris SF]]
[[Category: Wu P]]
Retrieved from "https://proteopedia.org/4obo"