2efd: Difference between revisions

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{{STRUCTURE_2efd|  PDB=2efd  |  SCENE=  }}
===Ara7/AtVps9a===
{{ABSTRACT_PUBMED_20833725}}


==Function==
==Ara7/AtVps9a==
[[http://www.uniprot.org/uniprot/Q9LT31_ARATH Q9LT31_ARATH]] Functions as guanine nucleotide exchange factor (GEF) for Rab small GTPases. Activates specifically RABF1, RABF2A and RABF2B proteins. Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development. Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.<ref>PMID:18055610</ref> <ref>PMID:20833725</ref> [[http://www.uniprot.org/uniprot/Q9SN68_ARATH Q9SN68_ARATH]] Endosomal protein that may be involved in endocytosis.<ref>PMID:20833725</ref>
<StructureSection load='2efd' size='340' side='right'caption='[[2efd]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2efd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFD FirstGlance]. <br>
[[2efd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFD OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efd OCA], [https://pdbe.org/2efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2efd RCSB], [https://www.ebi.ac.uk/pdbsum/2efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2efd ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020833725</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/VPS9A_ARATH VPS9A_ARATH] Functions as guanine nucleotide exchange factor (GEF) for Rab small GTPases. Activates specifically RABF1, RABF2A and RABF2B proteins. Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development. Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.<ref>PMID:18055610</ref> <ref>PMID:20833725</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2efd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2efd ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Ihara, K.]]
[[Category: Large Structures]]
[[Category: Uejima, T.]]
[[Category: Ihara K]]
[[Category: Wakatsuki, S.]]
[[Category: Uejima T]]
[[Category: Gef]]
[[Category: Wakatsuki S]]
[[Category: Gtpase]]
[[Category: Nucleotide]]
[[Category: Rab5]]
[[Category: Transport protein]]
[[Category: Vps9]]
Retrieved from "https://proteopedia.org/2efd"