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{{STRUCTURE_2g5x|  PDB=2g5x  |  SCENE=  }}
===Crystal structure of lychnin a type 1 Ribosome Inactivating Protein (RIP)===
{{ABSTRACT_PUBMED_2248976}}


==About this Structure==
==Crystal structure of lychnin a type 1 Ribosome Inactivating Protein (RIP)==
[[2g5x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lychnis_chalcedonica Lychnis chalcedonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G5X OCA].  
<StructureSection load='2g5x' size='340' side='right'caption='[[2g5x]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Silene_chalcedonica Silene chalcedonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G5X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g5x OCA], [https://pdbe.org/2g5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g5x RCSB], [https://www.ebi.ac.uk/pdbsum/2g5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g5x ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/2g5x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g5x ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ribosome-inactivating proteins (RIPs) similar to those already known (Stirpe &amp; Barbieri (1986) FEBS Lett. 195, 1-8) were purified from the seeds of Asparagus officinalis (two proteins, asparin 1 and 2), of Citrullus colocynthis (two proteins, colocin 1 and 2), of Lychnis chalcedonica (lychnin) and of Manihot palmata (mapalmin), from the roots of Phytolacca americana (pokeweed antiviral protein from roots, PAP-R) and from the leaves of Bryonia dioica (bryodin-L). The two latter proteins can be considered as isoforms, respectively, of previously purified PAP, from the leaves of P. americana, and of bryodin-R, from the roots of B. dioica. All proteins have an Mr at approx, 30,000, and an alkaline isoelectric point. Bryodin-L, colocins, lychnin and mapalmin are glycoproteins. All RIPs inhibit protein synthesis by a rabbit reticulocyte lysate and phenylalanine polymerization by isolated ribosomes and alter rRNA in a similar manner as the A-chain of ricin and related toxins (Endo et al. (1987) J. Biol. Chem. 262, 5908-5912).


==Reference==
Purification and properties of new ribosome-inactivating proteins with RNA N-glycosidase activity.,Bolognesi A, Barbieri L, Abbondanza A, Falasca AI, Carnicelli D, Battelli MG, Stirpe F Biochim Biophys Acta. 1990 Nov 30;1087(3):293-302. PMID:002248976<ref>PMID:002248976</ref>
<ref group="xtra">PMID:002248976</ref><references group="xtra"/><references/>
 
[[Category: Lychnis chalcedonica]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: RRNA N-glycosylase]]
</div>
[[Category: Bolognesi, A.]]
<div class="pdbe-citations 2g5x" style="background-color:#fffaf0;"></div>
[[Category: Falini, G.]]
 
[[Category: Fermani, S.]]
==See Also==
[[Category: Polito, L.]]
*[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]]
[[Category: Ripamonti, A.]]
== References ==
[[Category: Stirpe, F.]]
<references/>
[[Category: Tosi, G.]]
__TOC__
[[Category: Alpha-beta protein]]
</StructureSection>
[[Category: Hydrolase]]
[[Category: Large Structures]]
[[Category: Silene chalcedonica]]
[[Category: Bolognesi A]]
[[Category: Falini G]]
[[Category: Fermani S]]
[[Category: Polito L]]
[[Category: Ripamonti A]]
[[Category: Stirpe F]]
[[Category: Tosi G]]
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