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New page: left|200px<br /><applet load="2vpi" size="350" color="white" frame="true" align="right" spinBox="true" caption="2vpi, resolution 2.40Å" /> '''HUMAN GMP SYNTHETASE...
 
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[[Image:2vpi.jpg|left|200px]]<br /><applet load="2vpi" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2vpi, resolution 2.40&Aring;" />
'''HUMAN GMP SYNTHETASE- GLUTAMINASE DOMAIN'''<br />


==About this Structure==
==Human GMP synthetase - glutaminase domain==
2VPI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/GMP_synthase_(glutamine-hydrolyzing) GMP synthase (glutamine-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.5.2 6.3.5.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPI OCA].  
<StructureSection load='2vpi' size='340' side='right'caption='[[2vpi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: GMP synthase (glutamine-hydrolyzing)]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2vpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpi OCA], [https://pdbe.org/2vpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpi RCSB], [https://www.ebi.ac.uk/pdbsum/2vpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
== Function ==
[https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.<ref>PMID:8089153</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpi ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[GMP synthase|GMP synthase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van Den.]]
[[Category: Berglund H]]
[[Category: Berglund, H.]]
[[Category: Busam RD]]
[[Category: Busam, R D.]]
[[Category: Collins R]]
[[Category: Collins, R.]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Herman MD]]
[[Category: Herman, M D.]]
[[Category: Johansson I]]
[[Category: Johansson, I.]]
[[Category: Kallas A]]
[[Category: Kallas, A.]]
[[Category: Karlberg T]]
[[Category: Karlberg, T.]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T.]]
[[Category: Lehtio L]]
[[Category: Lehtio, L.]]
[[Category: Moche M]]
[[Category: Moche, M.]]
[[Category: Nilsson ME]]
[[Category: Nilsson, M E.]]
[[Category: Nordlund P]]
[[Category: Nordlund, P.]]
[[Category: Nyman T]]
[[Category: Nyman, T.]]
[[Category: Persson C]]
[[Category: Persson, C.]]
[[Category: Sagemark J]]
[[Category: Sagemark, J.]]
[[Category: Svensson L]]
[[Category: Sgc, Structural Genomics Consortium.]]
[[Category: Thorsell AG]]
[[Category: Svensson, L.]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G.]]
[[Category: Van Der Berg S]]
[[Category: Tresaugues, L.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Welin M]]
[[Category: Welin, M.]]
[[Category: atp-binding]]
[[Category: chromosomal rearrangement]]
[[Category: cytoplasm]]
[[Category: glutaminase domain]]
[[Category: glutamine amidotransferase]]
[[Category: gmp biosynthesis]]
[[Category: gmp synthetase]]
[[Category: gmp]]
[[Category: guanine monophosphate synthetase]]
[[Category: ligase]]
[[Category: nucleotide-binding]]
[[Category: phosphoprotein]]
[[Category: proto-oncogene]]
[[Category: purine biosynthesis]]
 
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Retrieved from "https://proteopedia.org/2vpi"