4kqu: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate==
==Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate==
<StructureSection load='4kqu' size='340' side='right' caption='[[4kqu]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='4kqu' size='340' side='right'caption='[[4kqu]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
[[4kqu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQU OCA]. <br>
<table><tr><td colspan='2'>[[4kqu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQU FirstGlance]. <br>
<b>Related:</b> [[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kq5|4kq5]], [[4kqs|4kqs]]<br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHD:4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE'>AHD</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
== References ==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqu OCA], [https://pdbe.org/4kqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqu RCSB], [https://www.ebi.ac.uk/pdbsum/4kqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqu ProSAT]</span></td></tr>
<references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
 
==See Also==
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Barnett, B L.]]
[[Category: Homo sapiens]]
[[Category: Muniz, J R.C.]]
[[Category: Large Structures]]
[[Category: Tsoumpra, M K.]]
[[Category: Barnett BL]]
[[Category: Walter, R L.]]
[[Category: Muniz JRC]]
[[Category: Bisphosphonate]]
[[Category: Tsoumpra MK]]
[[Category: Cholesterol synthesis]]
[[Category: Walter RL]]
[[Category: Dimethylallyl pyrophosphate]]
[[Category: Isoprene biosynthesis]]
[[Category: Isoprenoid pathway]]
[[Category: Lipid synthesis]]
[[Category: Steroid biosynthesis]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4kqu"