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==A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex==
==A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex==
<StructureSection load='2l8i' size='340' side='right' caption='[[2l8i]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
<StructureSection load='2l8i' size='340' side='right'caption='[[2l8i]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. <br>
<table><tr><td colspan='2'>[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8I FirstGlance]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
== Publication Abstract from PubMed ==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2L8:[(2R,3S,5R)-3-[(1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl+dihydrogen+phosphate'>2L8</scene></td></tr>
Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA.
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8i OCA], [https://pdbe.org/2l8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8i RCSB], [https://www.ebi.ac.uk/pdbsum/2l8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8i ProSAT]</span></td></tr>
 
</table>
Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.,Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102<ref>PMID:22131102</ref>
 
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Brown, T.]]
[[Category: Large Structures]]
[[Category: Dehmel, L.]]
[[Category: Brown T]]
[[Category: El-Sagheer, A.]]
[[Category: Dehmel L]]
[[Category: Ernsting, N.]]
[[Category: El-Sagheer A]]
[[Category: Griesinger, C.]]
[[Category: Ernsting N]]
[[Category: Mugge, C.]]
[[Category: Griesinger C]]
[[Category: Dna]]
[[Category: Mugge C]]
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