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==Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
==Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
<StructureSection load='2l33' size='340' side='right' caption='[[2l33]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l33' size='340' side='right'caption='[[2l33]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2l33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L33 OCA]. <br>
<table><tr><td colspan='2'>[[2l33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L33 FirstGlance]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l33 OCA], [https://pdbe.org/2l33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l33 RCSB], [https://www.ebi.ac.uk/pdbsum/2l33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l33 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l33_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l33_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l33 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Large Structures]]
[[Category: Ciccosanti, A.]]
[[Category: Acton TB]]
[[Category: Consortium, Northeast Structural Genomics.]]
[[Category: Ciccosanti A]]
[[Category: Everett, J.]]
[[Category: Everett J]]
[[Category: Janjua, H.]]
[[Category: Janjua H]]
[[Category: Liu, G.]]
[[Category: Liu G]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Shastry, R B.]]
[[Category: Xiao, R.]]
[[Category: Drbm]]
[[Category: Dsrna-binding]]
[[Category: Ilf3]]
[[Category: Nf90]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transcription regulator]]
[[Category: Shastry RB]]
[[Category: Xiao R]]
Retrieved from "https://proteopedia.org/2l33"