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==Solution NMR structure of N-terminal domain of human E3 ubiquitin-protein ligase HECW2, Northeast structural genomics consortium (NESG) target ht6306A==
==Solution NMR structure of N-terminal domain of human E3 ubiquitin-protein ligase HECW2, Northeast structural genomics consortium (NESG) target ht6306A==
<StructureSection load='2lfe' size='340' side='right' caption='[[2lfe]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
<StructureSection load='2lfe' size='340' side='right'caption='[[2lfe]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2lfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFE OCA]. <br>
<table><tr><td colspan='2'>[[2lfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFE FirstGlance]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
== References ==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfe OCA], [https://pdbe.org/2lfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfe RCSB], [https://www.ebi.ac.uk/pdbsum/2lfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfe ProSAT]</span></td></tr>
<references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HECW2_HUMAN HECW2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
 
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Chitayat, S.]]
[[Category: Arrowsmith C]]
[[Category: Dhe-Paganon, S.]]
[[Category: Chitayat S]]
[[Category: Garcia, M.]]
[[Category: Dhe-Paganon S]]
[[Category: Houliston, S.]]
[[Category: Garcia M]]
[[Category: Lemak, A.]]
[[Category: Houliston S]]
[[Category: Montelione, G T.]]
[[Category: Lemak A]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Yee A]]
[[Category: Yee, A.]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Sgc]]
[[Category: Structural genomic]]
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