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==Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A==
==Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A==
<StructureSection load='2lfh' size='340' side='right' caption='[[2lfh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lfh' size='340' side='right'caption='[[2lfh]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2lfh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFH OCA]. <br>
<table><tr><td colspan='2'>[[2lfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFH FirstGlance]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfh OCA], [https://pdbe.org/2lfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfh RCSB], [https://www.ebi.ac.uk/pdbsum/2lfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ID3_HUMAN ID3_HUMAN] ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.<ref>PMID:8437843</ref>  
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Large Structures]]
[[Category: Eletsky, A.]]
[[Category: Acton TB]]
[[Category: Everett, J K.]]
[[Category: Eletsky A]]
[[Category: Janjua, H.]]
[[Category: Everett JK]]
[[Category: Kohan, E.]]
[[Category: Janjua H]]
[[Category: Montelione, G T.]]
[[Category: Kohan E]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: Szyperski, T.]]
[[Category: Szyperski T]]
[[Category: Wang, D.]]
[[Category: Wang D]]
[[Category: Xiao, R.]]
[[Category: Xiao R]]
[[Category: Dna binding protein inhibitor]]
[[Category: Helix-loop-helix]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2lfh"