2l4n: Difference between revisions

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==Solution Structure of the Chemokine CCL21==
==Solution Structure of the Chemokine CCL21==
<StructureSection load='2l4n' size='340' side='right' caption='[[2l4n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l4n' size='340' side='right'caption='[[2l4n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l4n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4N OCA]. <br>
<table><tr><td colspan='2'>[[2l4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4N FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL21, RP11-195F19.22-001, SCYA21, UNQ784/PRO1600 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4n OCA], [https://pdbe.org/2l4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4n RCSB], [https://www.ebi.ac.uk/pdbsum/2l4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4n ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l4n RCSB], [http://www.ebi.ac.uk/pdbsum/2l4n PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/CCL21_HUMAN CCL21_HUMAN] Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 structure solved by NMR contains a conserved chemokine domain followed by an extended, unstructured C-terminus that is not typical of most other chemokines. A sedimentation equilibrium study showed CCL21 to be monomeric. Chemical shift mapping indicates that the CCR7 N-terminus binds to the N-loop and third beta-strand of CCL21's chemokine domain. Details of CCL21-receptor recognition may enable structure-based drug discovery of novel antimetastatic agents.
 
Solution structure of CCL21 and identification of a putative CCR7 binding site.,Love M, Sandberg JL, Ziarek JJ, Gerarden KP, Rode RR, Jensen DR, McCaslin DR, Peterson FC, Veldkamp CT Biochemistry. 2012 Jan 24;51(3):733-5. Epub 2012 Jan 17. PMID:22221265<ref>PMID:22221265</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2l4n" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Love, M.]]
[[Category: Large Structures]]
[[Category: Peterson, F C.]]
[[Category: Love M]]
[[Category: Sandberg, J L.]]
[[Category: Peterson FC]]
[[Category: Veldkamp, C T.]]
[[Category: Sandberg JL]]
[[Category: 6ckine]]
[[Category: Veldkamp CT]]
[[Category: Ccr7]]
[[Category: Chemokine]]
[[Category: Cytokine]]
[[Category: Exodus-2]]
[[Category: Slc]]
Retrieved from "https://proteopedia.org/2l4n"