2lkb: Difference between revisions
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==Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels== | ==Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels== | ||
<StructureSection load='2lkb' size='340' side='right' caption='[[2lkb | <StructureSection load='2lkb' size='340' side='right'caption='[[2lkb]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lkb]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKB FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkb OCA], [https://pdbe.org/2lkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkb RCSB], [https://www.ebi.ac.uk/pdbsum/2lkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkb ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SCXN5_MESEU SCXN5_MESEU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=790 nM) and drosophila DmNav1 (EC(50)=280 nM) (PubMed:21969612, Ref.2). The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612). Has antimicrobial activity (Ref.2).<ref>PMID:21969612</ref> [PROSITE-ProRule:PRU01210] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 12: | Line 15: | ||
Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels.,Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J Mol Cell Proteomics. 2011 Oct 3. PMID:21969612<ref>PMID:21969612</ref> | Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels.,Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J Mol Cell Proteomics. 2011 Oct 3. PMID:21969612<ref>PMID:21969612</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2lkb" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mesobuthus eupeus]] | [[Category: Mesobuthus eupeus]] | ||
[[Category: Cao | [[Category: Cao C]] | ||
[[Category: Gao | [[Category: Gao B]] | ||
[[Category: Lu | [[Category: Lu X]] | ||
[[Category: Peigneur | [[Category: Peigneur S]] | ||
[[Category: Tytgat | [[Category: Tytgat J]] | ||
[[Category: Zhu | [[Category: Zhu S]] | ||
