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==Crystal structure of the human DDR1 kinase domain==
 
<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
==Structure of the DDR1 kinase domain in complex with ponatinib==
<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. <br>
<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [https://pdbe.org/3zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [https://www.ebi.ac.uk/pdbsum/3zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3zos" style="background-color:#fffaf0;"></div>
==See Also==
*[[Epithelial discoidin domain-containing receptor|Epithelial discoidin domain-containing receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Bradley, A.]]
[[Category: Bradley A]]
[[Category: Bullock, A.]]
[[Category: Bullock A]]
[[Category: Canning, P.]]
[[Category: Canning P]]
[[Category: Coutandin, D.]]
[[Category: Coutandin D]]
[[Category: Delft, F von.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Elkins JM]]
[[Category: Elkins, J M.]]
[[Category: Goubin S]]
[[Category: Goubin, S.]]
[[Category: Mahajan P]]
[[Category: Mahajan, P.]]
[[Category: Von Delft F]]
[[Category: Collagen]]
[[Category: Discoidin domain]]
[[Category: Rtk]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3zos"