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==Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum==
==Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum==
<StructureSection load='4py6' size='340' side='right' caption='[[4py6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4py6' size='340' side='right'caption='[[4py6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4py6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY6 OCA]. <br>
<table><tr><td colspan='2'>[[4py6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PY6 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=R78:4-{[(7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>R78</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=R78:4-{[(7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>R78</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4py6 RCSB], [http://www.ebi.ac.uk/pdbsum/4py6 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4py6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py6 OCA], [https://pdbe.org/4py6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4py6 RCSB], [https://www.ebi.ac.uk/pdbsum/4py6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4py6 ProSAT]</span></td></tr>
<table>
</table>
== References ==
== Function ==
<references/>
[https://www.uniprot.org/uniprot/Q8I240_PLAF7 Q8I240_PLAF7]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Brennan, P E.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Bountra C]]
[[Category: Dong, A.]]
[[Category: Brennan PE]]
[[Category: Duffy, M F.]]
[[Category: Dong A]]
[[Category: Filippakopoulos, P.]]
[[Category: Duffy MF]]
[[Category: Fonseca, M.]]
[[Category: Filippakopoulos P]]
[[Category: Hui, R.]]
[[Category: Fonseca M]]
[[Category: Hutchinson, A.]]
[[Category: Hui R]]
[[Category: Josling, G A.]]
[[Category: Hutchinson A]]
[[Category: Knapp, S.]]
[[Category: Josling GA]]
[[Category: Krojer, T.]]
[[Category: Knapp S]]
[[Category: Loppnau, P.]]
[[Category: Krojer T]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Loppnau P]]
[[Category: Savitsky, P.]]
[[Category: Savitsky P]]
[[Category: Tallant, C.]]
[[Category: Tallant C]]
[[Category: Wernimont, A K.]]
[[Category: Wernimont AK]]
[[Category: Bromodomain]]
[[Category: Von Delft F]]
[[Category: Malaria]]
[[Category: Protein binding]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
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