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==DISTINCT AND ESSENTIAL MORPHOGENIC FUNCTIONS FOR WALL- AND LIPO-TEICHOIC ACIDS IN BACILLUS SUBTILIS==
 
<StructureSection load='2w8d' size='340' side='right' caption='[[2w8d]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
==Distinct and essential morphogenic functions for wall- and lipo- teichoic acids in Bacillus subtilis==
<StructureSection load='2w8d' size='340' side='right'caption='[[2w8d]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2w8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8D OCA]. <br>
<table><tr><td colspan='2'>[[2w8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8D FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8d OCA], [https://pdbe.org/2w8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8d RCSB], [https://www.ebi.ac.uk/pdbsum/2w8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8d ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w8d RCSB], [http://www.ebi.ac.uk/pdbsum/2w8d PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/LTAS2_BACSU LTAS2_BACSU] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.<ref>PMID:17483484</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w8d ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis.,Schirner K, Marles-Wright J, Lewis RJ, Errington J EMBO J. 2009 Apr 8;28(7):830-42. Epub 2009 Feb 19. PMID:19229300<ref>PMID:19229300</ref>
Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis.,Schirner K, Marles-Wright J, Lewis RJ, Errington J EMBO J. 2009 Apr 8;28(7):830-42. Epub 2009 Feb 19. PMID:19229300<ref>PMID:19229300</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2w8d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Errington, J.]]
[[Category: Large Structures]]
[[Category: Lewis, R J.]]
[[Category: Errington J]]
[[Category: Marles-Wright, J.]]
[[Category: Lewis RJ]]
[[Category: Schirner, K.]]
[[Category: Marles-Wright J]]
[[Category: B subtili]]
[[Category: Schirner K]]
[[Category: Cell membrane]]
[[Category: Cell wall]]
[[Category: Cell wall biogenesis/degradation acid]]
[[Category: Lipotechoic acid]]
[[Category: Lta]]
[[Category: Membrane]]
[[Category: Phosphatase]]
[[Category: Secreted]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Wta]]

Latest revision as of 08:01, 23 October 2024

Distinct and essential morphogenic functions for wall- and lipo- teichoic acids in Bacillus subtilis

2w8d, resolution 2.35Å

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