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==Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186==
==Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186==
<StructureSection load='4etk' size='340' side='right' caption='[[4etk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4etk' size='340' side='right'caption='[[4etk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4etk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETK OCA]. <br>
<table><tr><td colspan='2'>[[4etk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ETK FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v45|3v45]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4etk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4etk OCA], [https://pdbe.org/4etk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4etk RCSB], [https://www.ebi.ac.uk/pdbsum/4etk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4etk ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4etk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4etk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4etk RCSB], [http://www.ebi.ac.uk/pdbsum/4etk PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Design of activated serine-containing catalytic triads with atomic-level accuracy.,Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D Nat Chem Biol. 2014 Apr 6. doi: 10.1038/nchembio.1498. PMID:24705591<ref>PMID:24705591</ref>
Design of activated serine-containing catalytic triads with atomic-level accuracy.,Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D Nat Chem Biol. 2014 Apr 6. doi: 10.1038/nchembio.1498. PMID:24705591<ref>PMID:24705591</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4etk" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Synthetic construct sequences]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Synthetic construct]]
[[Category: Baker, D.]]
[[Category: Acton TB]]
[[Category: Everett, J K.]]
[[Category: Baker D]]
[[Category: Hunt, J F.]]
[[Category: Everett JK]]
[[Category: Kornhaber, G.]]
[[Category: Hunt JF]]
[[Category: Kornhaber, K.]]
[[Category: Kornhaber G]]
[[Category: Kuzin, A.]]
[[Category: Kornhaber K]]
[[Category: Montelione, G T.]]
[[Category: Kuzin A]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: Rajagopalan, S.]]
[[Category: Rajagopalan S]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman J]]
[[Category: Su, M.]]
[[Category: Su M]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Hydrolase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
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