2mhs: Difference between revisions
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==NMR Structure of human Mcl-1== | ==NMR Structure of human Mcl-1== | ||
<StructureSection load='2mhs' size='340' side='right' caption='[[2mhs | <StructureSection load='2mhs' size='340' side='right'caption='[[2mhs]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. <br> | <table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHS FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [https://pdbe.org/2mhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [https://www.ebi.ac.uk/pdbsum/2mhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhs ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 12: | Line 15: | ||
High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref> | High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2mhs" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Aoki K]] | ||
[[Category: | [[Category: Lewis J]] | ||
[[Category: | [[Category: Liu G]] | ||
[[Category: | [[Category: Poppe L]] | ||
[[Category: | [[Category: Szyperski T]] | ||
[[Category: | [[Category: Yamane H]] | ||
