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==Crystal structure of B. anthracis DHPS with interfacial compound 4: 5-(trifluoromethyl)-1,2-benzoxazol-3-amine==
==Crystal structure of B. anthracis DHPS with interfacial compound 4: 5-(trifluoromethyl)-1,2-benzoxazol-3-amine==
<StructureSection load='4nhv' size='340' side='right' caption='[[4nhv]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='4nhv' size='340' side='right'caption='[[4nhv]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nhv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NHV OCA]. <br>
<table><tr><td colspan='2'>[[4nhv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NHV FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2O6:5-(TRIFLUOROMETHYL)-1,2-BENZOXAZOL-3-AMINE'>2O6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.992&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nil|4nil]], [[4nir|4nir]], [[4nl1|4nl1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2O6:5-(TRIFLUOROMETHYL)-1,2-BENZOXAZOL-3-AMINE'>2O6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nhv OCA], [https://pdbe.org/4nhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nhv RCSB], [https://www.ebi.ac.uk/pdbsum/4nhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nhv ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nhv RCSB], [http://www.ebi.ac.uk/pdbsum/4nhv PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/Q81VW8_BACAN Q81VW8_BACAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase.,Hammoudeh DI, Date M, Yun MK, Zhang W, Boyd VA, Viacava Follis A, Griffith E, Lee RE, Bashford D, White SW ACS Chem Biol. 2014 Mar 27. PMID:24650357<ref>PMID:24650357</ref>
Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase.,Hammoudeh DI, Date M, Yun MK, Zhang W, Boyd VA, Viacava Follis A, Griffith E, Lee RE, Bashford D, White SW ACS Chem Biol. 2014 Mar 27. PMID:24650357<ref>PMID:24650357</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nhv" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydropteroate synthase]]
[[Category: Bacillus anthracis]]
[[Category: Hammoudeh, D I.]]
[[Category: Large Structures]]
[[Category: White, S W.]]
[[Category: Hammoudeh DI]]
[[Category: Paba]]
[[Category: White SW]]
[[Category: Pterin]]
[[Category: Tim barel]]
[[Category: Tim barrel]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4nhv"