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==Crystal structure of HIV-1 broadly neutralizing antibody PGT152==
==Crystal structure of HIV-1 broadly neutralizing antibody PGT152==
<StructureSection load='4nuj' size='340' side='right' caption='[[4nuj]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='4nuj' size='340' side='right'caption='[[4nuj]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nuj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUJ OCA]. <br>
<table><tr><td colspan='2'>[[4nuj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NUJ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.827&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nuj RCSB], [http://www.ebi.ac.uk/pdbsum/4nuj PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuj OCA], [https://pdbe.org/4nuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nuj RCSB], [https://www.ebi.ac.uk/pdbsum/4nuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuj ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6N089_HUMAN Q6N089_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers.,Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Pena AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB Immunity. 2014 Apr 22. pii: S1074-7613(14)00122-8. doi:, 10.1016/j.immuni.2014.04.008. PMID:24768348<ref>PMID:24768348</ref>
Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers.,Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Pena AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB Immunity. 2014 Apr 22. pii: S1074-7613(14)00122-8. doi:, 10.1016/j.immuni.2014.04.008. PMID:24768348<ref>PMID:24768348</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nuj" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blattner, C.]]
[[Category: Homo sapiens]]
[[Category: Wilson, I A.]]
[[Category: Large Structures]]
[[Category: Fab fragment]]
[[Category: Blattner C]]
[[Category: Hiv envelope]]
[[Category: Wilson IA]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]

Latest revision as of 03:20, 21 November 2024

Crystal structure of HIV-1 broadly neutralizing antibody PGT152

4nuj, resolution 1.83Å

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