4l8w: Difference between revisions
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==Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate== | ==Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate== | ||
<StructureSection load='4l8w' size='340' side='right' caption='[[4l8w]], [[Resolution|resolution]] 2.39Å' scene=''> | <StructureSection load='4l8w' size='340' side='right'caption='[[4l8w]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. < | <table><tr><td colspan='2'>[[4l8w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8W FirstGlance]. <br> | ||
</ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr> | |||
<tr><td class="sblockLbl"><b> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8w OCA], [https://pdbe.org/4l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8w RCSB], [https://www.ebi.ac.uk/pdbsum/4l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8w ProSAT]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/Q6NY42_DANRE Q6NY42_DANRE] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref> | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase.,Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF, Chen CJ J Med Chem. 2013 Oct 10;56(19):7625-35. doi: 10.1021/jm401013e. Epub 2013 Sep 27. PMID:24028568<ref>PMID:24028568</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4l8w" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Danio rerio]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Chuankhayan | [[Category: Chen C-J]] | ||
[[Category: Fu | [[Category: Chuankhayan P]] | ||
[[Category: Kao | [[Category: Fu T-F]] | ||
[[Category: Kao T-T]] | |||
Latest revision as of 14:33, 8 November 2023
Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate
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