4cpm: Difference between revisions
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==Structure of the Neuraminidase from the B/Brisbane/60/2008 virus in complex with Oseltamivir== | ==Structure of the Neuraminidase from the B/Brisbane/60/2008 virus in complex with Oseltamivir== | ||
<StructureSection load='4cpm' size='340' side='right' caption='[[4cpm]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='4cpm' size='340' side='right'caption='[[4cpm]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cpm]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4cpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Brisbane/60/2008) Influenza B virus (B/Brisbane/60/2008)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPM FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand= | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpm OCA], [https://pdbe.org/4cpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpm RCSB], [https://www.ebi.ac.uk/pdbsum/4cpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpm ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/C0LT34_9INFB C0LT34_9INFB] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
A novel I221 L substitution in neuraminidase confers high level resistance to oseltamivir in influenza B viruses.,Escuret V, Collins PJ, Casalegno JS, Vachieri SG, Cattle N, Ferraris O, Sabatier M, Frobert E, Caro V, Skehel JJ, Gamblin S, Valla F, Valette M, Ottmann M, McCauley JW, Daniels RS, Lina B J Infect Dis. 2014 May 3. PMID:24795482<ref>PMID:24795482</ref> | A novel I221 L substitution in neuraminidase confers high level resistance to oseltamivir in influenza B viruses.,Escuret V, Collins PJ, Casalegno JS, Vachieri SG, Cattle N, Ferraris O, Sabatier M, Frobert E, Caro V, Skehel JJ, Gamblin S, Valla F, Valette M, Ottmann M, McCauley JW, Daniels RS, Lina B J Infect Dis. 2014 May 3. PMID:24795482<ref>PMID:24795482</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4cpm" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Caro | [[Category: Caro V]] | ||
[[Category: Casalegno | [[Category: Casalegno JS]] | ||
[[Category: Cattle | [[Category: Cattle N]] | ||
[[Category: Collins | [[Category: Collins PJ]] | ||
[[Category: Daniels | [[Category: Daniels RS]] | ||
[[Category: Escuret | [[Category: Escuret V]] | ||
[[Category: Ferraris | [[Category: Ferraris O]] | ||
[[Category: Frobert | [[Category: Frobert E]] | ||
[[Category: Gamblin | [[Category: Gamblin SJ]] | ||
[[Category: Lina | [[Category: Lina B]] | ||
[[Category: McCauley | [[Category: McCauley JW]] | ||
[[Category: Ottmann | [[Category: Ottmann M]] | ||
[[Category: Sabatier | [[Category: Sabatier M]] | ||
[[Category: Skehel | [[Category: Skehel JJ]] | ||
[[Category: Vachieri | [[Category: Vachieri SG]] | ||
[[Category: Valette | [[Category: Valette M]] | ||
[[Category: Valla | [[Category: Valla F]] | ||
Latest revision as of 12:14, 20 December 2023
Structure of the Neuraminidase from the B/Brisbane/60/2008 virus in complex with Oseltamivir
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