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==CRYSTAL STRUCTURE OF HUMAN NDRG2 PROTEIN PROVIDES INSIGHT INTO ITS ROLE AS A TUMOR SUPPRESSOR==
 
<StructureSection load='2xms' size='340' side='right' caption='[[2xms]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
==Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor==
<StructureSection load='2xms' size='340' side='right'caption='[[2xms]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xms]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XMS OCA]. <br>
<table><tr><td colspan='2'>[[2xms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XMS FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xmr|2xmr]], [[2xmq|2xmq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xms OCA], [https://pdbe.org/2xms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xms RCSB], [https://www.ebi.ac.uk/pdbsum/2xms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xms ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xms OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xms RCSB], [http://www.ebi.ac.uk/pdbsum/2xms PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/NDRG2_HUMAN NDRG2_HUMAN] Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.<ref>PMID:12845671</ref> <ref>PMID:16103061</ref> <ref>PMID:21247902</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor.,Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH J Biol Chem. 2011 Jan 18. PMID:21247902<ref>PMID:21247902</ref>
Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor.,Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH J Biol Chem. 2011 Jan 18. PMID:21247902<ref>PMID:21247902</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xms" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hwang, J.]]
[[Category: Large Structures]]
[[Category: Kim, M H.]]
[[Category: Hwang J]]
[[Category: Kim, Y.]]
[[Category: Kim MH]]
[[Category: Lee, H.]]
[[Category: Kim Y]]
[[Category: Ndrg family]]
[[Category: Lee H]]
[[Category: Signaling protein]]
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